Thanks to Promobricks, we now have the first details on which LEGO City sets to expect in the first wave of 2021. If you're interested in finding out which LEGO City sets are retiring this year, you can check out the Retiring Soon page to see the comprehensive list.
It seems that thematically, the first wave of 2022 will focus heavily on the Emergency Responders sub-theme of LEGO City, and the most notable of this wave is the newest iteration of the LEGO City Hospital (the last version released back in 2018). We're also going to be getting the first Official LEGO City School in the history of the theme, which will also include a School Bus to go along with the set! There will also be a return of some construction-themed vehicles, which will be the first major return of these types of sets since the Mining Sub-theme in 2018.
60312 Police Car 51 parts $9.99 01/01/2022
60314 Ice Cream Van Pursuit 317 parts $29.99 01/01/2022
60315 Mobile Command Center 436 parts $39.99 01/01/2022
60316 Police Station 668 parts $59.99 01/01/2022
60317 Bank Robbery 915 parts $99.99 01/01/2022
60318 Fire Helicopter 53 parts $9.99 01/01/2022
60319 Fire Fighter's Drone 295 parts $29.99 01/01/2022
60320 Fire Station 540 parts $59.99 01/01/2022
60321 Fire Brigade Operation 766 parts $99.99 01/01/2022
60322 Race Car 46 parts $9.99 01/01/2022
60323 Stunt Plane 59 parts $9.99 01/01/2022
60324 Rough Terrain Crane 340 parts $39.99 01/01/2022
60325 Concrete Mixer 85 parts $19.99 01/01/2022
60326 Picnic in the Park N/A $19.99 01/01/2022
60327 Horse Transport N/A $29.99 01/01/2022
60328 Lifeguard Station 211 parts $29.99 01/01/2022
60329 School with School Bus 433 parts $59.99 01/01/2022
60330 Hospital 816 parts $99.99 01/01/2022
60343 Helicopter Transporter 212 parts $29.99 01/01/2022